About: Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation

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About: Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We have described an N-terminally truncated p53 protein (p53/47) which can interact with p53 and impose altered stability and transactivation properties to p53 complexes. Changes in synthesis of full-length p53 or p53/47 are regulated through distinct cell stress-induced pathways acting through separate regions of the p53 mRNA. We also show that some cytotoxic drugs require the presence of full-length p53 to induce apoptosis, whereas for others p53/47 is sufficient. We have described an N-terminally truncated p53 protein (p53/47) which can interact with p53 and impose altered stability and transactivation properties to p53 complexes. Changes in synthesis of full-length p53 or p53/47 are regulated through distinct cell stress-induced pathways acting through separate regions of the p53 mRNA. We also show that some cytotoxic drugs require the presence of full-length p53 to induce apoptosis, whereas for others p53/47 is sufficient. (en) Popsali jsme na N-konci zkrácenou formu proteinu p53 (p53/47), která může interagovat s p53 a ovlivňovat tak stabilitu a transaktivační schopnosti komplexů p53. Změny v tvorbě p53 a/nebo p53/47 jsou v buňce regulovány různými stresem indukovanými dráhami. Dále ukazujeme, že některé cytotoxické látky indukují apoptózu jen v přítomnosti p53, zatímco u jiných látek stačí k indukci apoptózy přítomnost p53/47. (cs)
Title	Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation (en) Exprese p53 a p53/47 je kontrolována alternativním mechanismem iniciace translace mediátorové RNA (cs)
skos:prefLabel	Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation (en) Exprese p53 a p53/47 je kontrolována alternativním mechanismem iniciace translace mediátorové RNA (cs)
skos:notation	RIV/00209805:_____/06:0000020!RIV07-MZ0-00209805
http://linked.open.../vavai/riv/strany	6936; 6947
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR8338)
http://linked.open...iv/cisloPeriodika	52
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Vojtěšek, Bořivoj
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	475342
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/06:0000020
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	p53, p53/47, stress response, alternative translation initiation (en)
http://linked.open.../riv/klicoveSlovo	p53 alternative translation initiation stress response p53/47
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[64982DD84EF3]
http://linked.open...i/riv/nazevZdroje	Oncogene
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional analysis of the p53-dependent pathways in breast cancer: Integration of genomic and proteomic approaches using DNA-macroarray and SELDI-TOF mass spectrometry techniques
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Vojtěšek, Bořivoj
issn	0950-9232
number of pages	12 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation

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