About: Why negative meta-analyses may be false?

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0924977X13000394#
Description	Results of meta-analyses are regarded as the highest level of evidence. A statistically non-significant effect size from a meta-analysis is typically considered true negative even in the presence of a statistically significant signal in individual studies, presumed to be false positive. Here we provide examples from neuroimaging, genetics and psychopharmacology of why meta-analyses may frequently yield false negative results from true positive findings. This may happen in situations when individual studies report findings in opposing directions, the sum of which yields a non-significant overall effect size. Such non-significant meta-analyses, which show statistical heterogeneity and include studies with opposing effect sizes do not provide an accurate estimate of the overall effect and may have lower heuristic value than individual studies. Over reliance on such meta-analyses may falsely identify certain potentially fruitful research avenues as blind alleys. Results of meta-analyses are regarded as the highest level of evidence. A statistically non-significant effect size from a meta-analysis is typically considered true negative even in the presence of a statistically significant signal in individual studies, presumed to be false positive. Here we provide examples from neuroimaging, genetics and psychopharmacology of why meta-analyses may frequently yield false negative results from true positive findings. This may happen in situations when individual studies report findings in opposing directions, the sum of which yields a non-significant overall effect size. Such non-significant meta-analyses, which show statistical heterogeneity and include studies with opposing effect sizes do not provide an accurate estimate of the overall effect and may have lower heuristic value than individual studies. Over reliance on such meta-analyses may falsely identify certain potentially fruitful research avenues as blind alleys. (en)
Title	Why negative meta-analyses may be false? Why negative meta-analyses may be false? (en)
skos:prefLabel	Why negative meta-analyses may be false? Why negative meta-analyses may be false? (en)
skos:notation	RIV/00023752:_____/13:43914493!RIV14-MZ0-00023752
http://linked.open...avai/predkladatel	Psychiatrické centrum Praha
http://linked.open...avai/riv/aktivita	N V
http://linked.open...avai/riv/aktivity	N, V
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Höschl, Cyril Kopeček, Miloslav Alda, Martin Hájek, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	117359
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/13:43914493
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	statistical heterogeneity; false negative; meta-analyses (en)
http://linked.open.../riv/klicoveSlovo	false negative meta-analyses statistical heterogeneity
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[595DE2A036C9]
http://linked.open...i/riv/nazevZdroje	European Neuropsychopharmacology
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Alda, Martin Hájek, Tomáš Höschl, Cyril Kopeček, Miloslav Uher, Rudolf
http://linked.open...ain/vavai/riv/wos	000325833500018
issn	0924-977X
number of pages	3 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.euroneuro.2013.01.004

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