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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Amikacin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Carbohydrate
Preferred_Name
  • Amikacin
UMLS_CUI
  • C0002499
CAS_Registry
  • 37517-28-5
FDA_UNII_Code
  • 84319SGC3C
Contributing_Source
  • FDA
ALT_DEFINITION
  • An antibiotic drug used to treat infection. It belongs to the family of drugs called aminoglycoside antibiotics.NCI-GLOSS
Chemical_Formula
  • C22H43N5O13
Legacy_Concept_Name
  • Amikacin_Base
CHEBI_ID
  • CHEBI:2637
FULL_SYN
  • AMIKACINPTFDA84319SGC3C
  • AmikacinSYDTPNSC0177001
  • amikacinPTNCI-GLOSSCDR0000045174
  • AmikacinPTNCI
DEFINITION
  • A broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically locking 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and , misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria.NCI
code
  • C61615
sameAs
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