About: Amikacin Sulfate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Amikacin Sulfate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Carbohydrate
Preferred_Name
  • Amikacin Sulfate
NSC_Code
  • 177001
UMLS_CUI
  • C0700949
CAS_Registry
  • 39831-55-5
FDA_UNII_Code
  • N6M33094FD
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39145
PDQ_Closed_Trial_Search_ID
  • 39145
Chemical_Formula
  • C22H43N5O13.2H2O4S
Legacy_Concept_Name
  • Amikacin
CHEBI_ID
  • CHEBI:2638
FULL_SYN
  • AMIKACIN SULFATEPTFDAN6M33094FD
  • Amikacin SulfatePTNCI
  • AmikinBRNCI
DEFINITION
  • The sulfate salt of amikacin, a broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically in contact with 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria.NCI
code
  • C230
sameAs
http://linked.open...y/mesh/hasConcept
is someValuesFrom of
is Has_Salt_Form of
is sameAs of
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