About: Mutated Ras Peptide

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Mutated Ras Peptide
rdfs:subClassOf	Vaccine Antigen nodeID://b694227 nodeID://b694228
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
Preferred_Name	Mutated Ras Peptide
UMLS_CUI	C1513777
Legacy_Concept_Name	Mutated_Ras_Peptide
FULL_SYN	Ras Peptides (mutated)SYNCI Mutated Ras PeptidePTNCI
DEFINITION	Point-mutation products of Ras proto-oncogene are found to associated with a broad spectrum of human carcinomas. Mutation locations are notably at codons 12, 13, and 61. Codon 12 mutations form more than 90% of all Ras mutations in human cancers. Degraded Ras peptides have been shown to stimulate immunogenic response. Various forms of mutated Ras peptides-adjuvant are used as vaccine along with cytokines that could potentially enhance the body's immunological response in many neoplastic conditions. (NCI04)NCI
code	C2730
is rdfs:subClassOf of	PR18 (ras-13 Cys) Peptide Ras Peptide ASP Ras Peptide CYS Ras Peptide VAL K-RAS ASP-12 Mutant Protein K-RAS ASP-13 Mutant Protein K-RAS GLY-12 Mutant Protein K-RAS VAL-12 Mutant Protein KRAS CYS-12 Mutant Protein PR-54 (ras-13 Asp) Peptide PR-5V10 (ras-12 Val) Peptide PR6V10 (ras-12 Asp) Peptide PR7V10 (ras-12 Ala) Peptide PR18 (ras-12CYS) Peptide

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