About: Retinoid X Receptor     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Retinoid X Receptor
rdfs:subClassOf
Semantic_Type
  • Receptor
Preferred_Name
  • Retinoid X Receptor
UMLS_CUI
  • C0140283
Legacy_Concept_Name
  • Retinoid-X_Receptor
FULL_SYN
  • Nuclear Receptor Subfamily 2 Group BSYNCI
  • RXRSYNCI
  • Retinoic Acid Receptor RXRSYNCI
  • Retinoid X ReceptorPTNCI
DEFINITION
  • Human nuclear Retinoid X Receptors RXRA, RXRB, and RXRG (NR2/RXR Family) are transcriptional regulators composed of N-terminal modulating domain, DNA-binding domain (AGGTCA response elements), and C-terminal 9-cis RA-binding domain. RXR homodimers and RXR/RAR heterodimers mediate distinct retinoic acid response pathways. RXRs also interact with TH- and vitamin D receptors, and with NCOA3, NCOA6, PML, and PPARG coactivators; and mediate RA biological effects by binding to specific target gene promoters and inducing target gene transcription. RXRs/LXRs and RXRs/FXR may mediate cholesterol homeostasis, by governing cholesterol transport from peripheral cells, inhibiting cholesterol absorption in the small intestine, and repressing bile acid synthesis through upregulation of ABC1 and repression of CYP7A1 expression. (NCI)NCI
code
  • C17534
sameAs
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