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AttributesValues
rdf:type
rdfs:label
  • Topoisomerase Inhibitor
rdfs:subClassOf
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • Topoisomerase Inhibitor
UMLS_CUI
  • C0598317
ALT_DEFINITION
  • A substance that blocks topoisomerases (enzymes that break and rejoin DNA strands and are needed for cells to divide and grow). Blocking these enzymes may kill cancer cells. Certain topoisomerase inhibitors are being studied in the treatment of cancer.NCI-GLOSS
Legacy_Concept_Name
  • Topoisomerase_Inhibitor
FULL_SYN
  • topoisomerase inhibitorPTNCI-GLOSSCDR0000046665
  • Topoisomerase InhibitorPTNCI
  • Topoisomerase InhibitorsSYNCI
  • DNA Topoisomerase InhibitorsSYNCI
DEFINITION
  • Any substance that inhibits topoisomerase, an enzyme that cleaves the DNA backbone to relieve torsional stress in a DNA molecule generated during replication, transcription, and other structural transformations. Inhibition of topoisomerase causes DNA damage, inhibition of DNA replication, and apoptosis.NCI
code
  • C1748
is rdfs:subClassOf of
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