About: ALK Inhibitor RO5424802     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • ALK Inhibitor RO5424802
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • ALK Inhibitor RO5424802
PDQ_Open_Trial_Search_ID
  • 747398
PDQ_Closed_Trial_Search_ID
  • 747398
FULL_SYN
  • ALK Inhibitor RO5424802PTNCI
  • RO5424802CNNCI
DEFINITION
  • An orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, ALK inhibitor RO5424802 binds to and inhibits ALK kinase, which leads to a disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors. Additionally, ALK mutations are associated with acquired resistance to small molecule tyrosine kinase inhibitors.NCI
code
  • C105615
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