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rdf:type
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Description
| - Strategies to prevent and treat obesity aim to decrease energy intake and/or increase energy expenditure. Thus, ectopic expression of brown fat-specific mitochondrial uncoupling protein 1 (UCP1) elicited major metabolic effects both at the cellular/tissue level and at the whole-body level. The consequences of mitochondrial uncoupling in WAT and SM are not identical, showing robust and stable obesity resistance accompanied by improvement of lipid metabolism in the case of ectopic UCP1 in WAT, while preservation of insulin sensitivity in the context of high-fat feeding represents the major outcome of muscle UCP1 expression. These complex responses could be largely explained by tissue-specific activation of AMPK, triggered by a depression of cellular energy charge
- Strategies to prevent and treat obesity aim to decrease energy intake and/or increase energy expenditure. Thus, ectopic expression of brown fat-specific mitochondrial uncoupling protein 1 (UCP1) elicited major metabolic effects both at the cellular/tissue level and at the whole-body level. The consequences of mitochondrial uncoupling in WAT and SM are not identical, showing robust and stable obesity resistance accompanied by improvement of lipid metabolism in the case of ectopic UCP1 in WAT, while preservation of insulin sensitivity in the context of high-fat feeding represents the major outcome of muscle UCP1 expression. These complex responses could be largely explained by tissue-specific activation of AMPK, triggered by a depression of cellular energy charge (en)
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Title
| - Augmenting energy expenditure by mitochondrial uncoupling: a role of AMP-activated protein kinase
- Augmenting energy expenditure by mitochondrial uncoupling: a role of AMP-activated protein kinase (en)
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skos:prefLabel
| - Augmenting energy expenditure by mitochondrial uncoupling: a role of AMP-activated protein kinase
- Augmenting energy expenditure by mitochondrial uncoupling: a role of AMP-activated protein kinase (en)
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skos:notation
| - RIV/67985823:_____/12:00377925!RIV13-MZ0-67985823
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http://linked.open...avai/predkladatel
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(7E10059), P(NS10528), P(OC08008), Z(AV0Z50110509)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/67985823:_____/12:00377925
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - adipose tissue; skeletal muscle; uncoupling protein; transgenic mice; insulin sensitivity (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
| |
http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
| |
http://linked.open...iv/tvurceVysledku
| - Kopecký, Jan
- Rossmeisl, Martin
- Keipert, S.
- Klaus, S.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1007/s12263-011-0260-8
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is http://linked.open...avai/riv/vysledek
of | |