About: Highly Dynamic Exon Shuffling in Candidate Pathogen Receptors ? What if Brown Algae Were Capable of Adaptive Immunity?

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Pathogen recognition is often mediated by a wealth of fast-evolving receptors, many of which contain ligand-binding and signal transduction domains, such as leucine-rich or tetratricopeptide repeat (LRR/TPR) and NB-ARC domains, respectively. We mined the genome of the brown alga Ectocarpus siliculosus for homologues of these genes and assessed the evolutionary pressures acting upon them. We thus annotated all Ectocarpus LRR-containing genes, in particular an original group of LRR-containing GTPases of the ROCO family, and 24 NB-ARC-TPR proteins. They exhibit high birth and death rates, while a diversifying selection is acting on their LRR (respectively TPR) domain, probably affecting the ligand-binding specificities. Remarkably, each repeat is encoded by an exon, and the intense exon shuffling underpins the variability of LRR and TPR domains. The Ectocarpus ROCO and NB-ARC-TPR families are thus excellent candidates for being involved in recognition/transduction events linked to immunity. Pathogen recognition is often mediated by a wealth of fast-evolving receptors, many of which contain ligand-binding and signal transduction domains, such as leucine-rich or tetratricopeptide repeat (LRR/TPR) and NB-ARC domains, respectively. We mined the genome of the brown alga Ectocarpus siliculosus for homologues of these genes and assessed the evolutionary pressures acting upon them. We thus annotated all Ectocarpus LRR-containing genes, in particular an original group of LRR-containing GTPases of the ROCO family, and 24 NB-ARC-TPR proteins. They exhibit high birth and death rates, while a diversifying selection is acting on their LRR (respectively TPR) domain, probably affecting the ligand-binding specificities. Remarkably, each repeat is encoded by an exon, and the intense exon shuffling underpins the variability of LRR and TPR domains. The Ectocarpus ROCO and NB-ARC-TPR families are thus excellent candidates for being involved in recognition/transduction events linked to immunity. (en)
Title	Highly Dynamic Exon Shuffling in Candidate Pathogen Receptors ? What if Brown Algae Were Capable of Adaptive Immunity? Highly Dynamic Exon Shuffling in Candidate Pathogen Receptors ? What if Brown Algae Were Capable of Adaptive Immunity? (en)
skos:prefLabel	Highly Dynamic Exon Shuffling in Candidate Pathogen Receptors ? What if Brown Algae Were Capable of Adaptive Immunity? Highly Dynamic Exon Shuffling in Candidate Pathogen Receptors ? What if Brown Algae Were Capable of Adaptive Immunity? (en)
skos:notation	RIV/61988987:17310/12:A130176A!RIV13-GA0-17310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP305/10/0205)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Eliáš, Marek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ostravská univerzita v Ostravě / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	139006
http://linked.open...ai/riv/idVysledku	RIV/61988987:17310/12:A130176A
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	brown alga; Ectocarpus; exon shuffling; resistance gene analogue; innate immunity; adaptive immunity (en)
http://linked.open.../riv/klicoveSlovo	adaptive immunity innate immunity Ectocarpus brown alga exon shuffling resistance gene analogue
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[573233E2AF98]
http://linked.open...i/riv/nazevZdroje	MOL BIOL EVOL
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	The Ras superfamily of GTPases and the evolution of the eukaryotic cell
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Eliáš, Marek Gachon, Claire M. M. Maumus, Florian Sterck, Lieven Zambounis, Antonios
http://linked.open...ain/vavai/riv/wos	000302018100015
issn	0737-4038
number of pages	14 (xsd:int)
http://localhost/t...ganizacniJednotka	17310
is http://linked.open...avai/riv/vysledek of	Highly Dynamic Exon Shuffling in Candidate Pathogen Receptors ? What if Brown Algae Were Capable of Adaptive Immunity?

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