About: Formation of Secretory Senescent Cells in Prostate Tumors: The Role of Androgen Receptor Activity and Cell Cycle Regulation     Goto   Sponge   NotDistinct   Permalink

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  • The induction of senescence in cancer cells is believed to be a potent mechanism of tumor suppression; however, senescent cells remain metabolically active and secrete a broad spectrum of factors, modulate the tissue microenvironment, and potentially promote tumorigenicity in neighboring malignant cells. Another important subpopulation of secretory cells modulating the prostate tissue microenvironment is represented by neuroendocrine cells. Interestingly, androgen deprivation therapy, a widely used treatment for advanced prostate cancer, induces both the emergence of neuroendocrine-like prostate cancer cells and the senescence-associated secretory phenotype in prostate cancer epithelial cells.
  • The induction of senescence in cancer cells is believed to be a potent mechanism of tumor suppression; however, senescent cells remain metabolically active and secrete a broad spectrum of factors, modulate the tissue microenvironment, and potentially promote tumorigenicity in neighboring malignant cells. Another important subpopulation of secretory cells modulating the prostate tissue microenvironment is represented by neuroendocrine cells. Interestingly, androgen deprivation therapy, a widely used treatment for advanced prostate cancer, induces both the emergence of neuroendocrine-like prostate cancer cells and the senescence-associated secretory phenotype in prostate cancer epithelial cells. (en)
Title
  • Formation of Secretory Senescent Cells in Prostate Tumors: The Role of Androgen Receptor Activity and Cell Cycle Regulation
  • Formation of Secretory Senescent Cells in Prostate Tumors: The Role of Androgen Receptor Activity and Cell Cycle Regulation (en)
skos:prefLabel
  • Formation of Secretory Senescent Cells in Prostate Tumors: The Role of Androgen Receptor Activity and Cell Cycle Regulation
  • Formation of Secretory Senescent Cells in Prostate Tumors: The Role of Androgen Receptor Activity and Cell Cycle Regulation (en)
skos:notation
  • RIV/00216224:14110/13:00068061!RIV14-MSM-14110___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(ED1.100/02/0123), Z(MSM0021622430)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 75526
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  • RIV/00216224:14110/13:00068061
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http://linked.open.../riv/klicovaSlova
  • prostate cancer; senescence; neuroendocrine differentiation; senescence-associated secretory phenotype; androgen receptor; Skp2 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [3B1FC98AEB36]
http://linked.open...i/riv/mistoVydani
  • Dordrecht
http://linked.open...vEdiceCisloSvazku
  • Aging, Cancer, and Noncancer Pathologies, Vol. 1
http://linked.open...i/riv/nazevZdroje
  • Tumor Dormancy, Quiescence and Senescence
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...v/pocetStranKnihy
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Pernicová, Zuzana
  • Souček, Karel
  • Vaňhara, Petr
http://linked.open...n/vavai/riv/zamer
number of pages
http://bibframe.org/vocab/doi
  • 10.1007/978-94-007-5958-9_26
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  • Springer Science+Business Media
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  • 9789400759572
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  • 14110
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