About: Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Defects in either of the two cooperating tumor suppressors, p53 or ATM, confer an inferior prognosis for B CLL patients. The abnormalities were reported to be associated with the unmutated IgVH subtype and may thus arise as a consequence of its more aggressive behaviour. However a recent report has also clearly correlated the p53 inactivation to a DNA damaging chemotherapy including alkylating agents (Sturm et al., Cell Death Differ 2003, 10: 477 to 484). We performed a comprehensive determination of p53 status in 168 B CLL samples (including functional FASAY analysis) and a deletion screening of ATM locus in 69% of the corresponding samples and correlated the data to the IgVH mutation status and to previous treatment. Inactivation of the p53 (overall frequency 12%) occurred markedly more frequently (P 0.05) and deletions of ATM (overall frequency 18%) strictly (P 0.001) in the unmutated IgVH subtype. Defects in either of the two cooperating tumor suppressors, p53 or ATM, confer an inferior prognosis for B CLL patients. The abnormalities were reported to be associated with the unmutated IgVH subtype and may thus arise as a consequence of its more aggressive behaviour. However a recent report has also clearly correlated the p53 inactivation to a DNA damaging chemotherapy including alkylating agents (Sturm et al., Cell Death Differ 2003, 10: 477 to 484). We performed a comprehensive determination of p53 status in 168 B CLL samples (including functional FASAY analysis) and a deletion screening of ATM locus in 69% of the corresponding samples and correlated the data to the IgVH mutation status and to previous treatment. Inactivation of the p53 (overall frequency 12%) occurred markedly more frequently (P 0.05) and deletions of ATM (overall frequency 18%) strictly (P 0.001) in the unmutated IgVH subtype. (en)
Title	Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation (en)
skos:prefLabel	Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation (en)
skos:notation	RIV/00216224:14110/06:00019161!RIV11-MZ0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR8068), P(NR8443), P(NR8445), P(NR8448), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	20
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Vorlíček, Jiří Kuhrová, Viera Pospíšilová, Šárka Dvořáková, Dana Brychtová, Yvona Kuglík, Petr Mentzlová, Dita Doubek, Michael Mayer, Jiří Šmardová, Jana Malčíková, Jitka Trbušek, Martin Čejková, Soňa
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	479143
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/06:00019161
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	B-CLL FASAY IgVH p53 ATM previous treatment (en)
http://linked.open.../riv/klicoveSlovo	B-CLL FASAY IgVH p53 ATM previous treatment
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[054D5D1ABB64]
http://linked.open...i/riv/nazevZdroje	Leukemia
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	13 (xsd:int)
http://linked.open...cetTvurcuVysledku	17 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional analysis of temperature sensitive mutants of tumor suppressor p53 Molecular diagnosis of the lymphoproliferative disorders with methods of analysis of DNA, RNA and proteins: application of results in clinical praxis In vitro sensitivity/resistance of CLL cells with inactivated p53 on modern therapy Characterization of leukemia cell gene expression using DNA microarrays and its utilization for molecular diagnostics and therapy response prediction
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	2006
http://linked.open...iv/tvurceVysledku	Brychtová, Yvona Doubek, Michael Dvořáková, Dana Kuglík, Petr Mayer, Jiří Pospíšilová, Šárka Vorlíček, Jiří Malčíková, Jitka Svitáková, Miluše Trbušek, Martin Šmardová, Jana Mentzlová, Dita Čejková, Soňa Začal, Jiří Kuhrová, Viera Kujíčková, Jitka Linková, Věra
http://linked.open...ain/vavai/riv/wos	000237806500035
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	0887-6924
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation

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