| Attributes | Values |
|---|
| rdf:type
| |
| rdfs:seeAlso
| |
| Description
| - Annotation I. Clinical study of mutual interactions and particular role of fundamental cardiometabolic related mechanisms in diabetes mellitus; analysis of impact of therapeutical intervention on parameters of insulin resistance. Annotation II. Project will investigate changes, correlation and possible influencing by means of 7-days controlled fasting and/or 21-days low calorie diet (150g sacharides, 5000 kJ dialy) in the obese diabetic patients type 1 and 2 of the i) insulin resistance related to inflammation, ii) insulin-stimulated substrate utilization in insulin resistance, iii) body composition, iv) cholesterol biosynthetic/absorption pathway, v) endothelial dysfunction. Annotation III. The results might improve our knowledge and thus treatment of advanced cardiometabolic risk in diabetes mellitus, which is the leading cause of morbidity and mortality of patients in Czech Republic. (en)
- Anotace 1: Klinická studie vzájemné vazby a úlohy základních kardiometabolických mechanismů diabetes mellitus; vliv léčebné intervence na vývoj klinického stavu a parametry insulinové rezistence. Anotace 2: Projekt bude studovat význam, změny, vzájemnou korelaci a specifický vliv 7-denního hladovění resp. 21-denní redukční diety (150 g sacharidů, 5000 kJ denně) u obésních diabetiků 1. a 2. typu na i) parametry insulinové rezistence a mikroinflamace, ii) inzulinem-stimulovanou utilizaci substrátů, iii) složení tělesných kompartmentů , iv) biosyntézu a absorpci cholesterolu, v) endoteliální dysfunkci. Anotace 3: Závěrů projektu bude využito v klinické praxi, s cílem stanovit optimální léčebné strategie v intervenci insulinové resistence a kardiometabolického rizika diabetiků, které jsou významnou příčinou mortality a morbidity v České republice.
|
| Title
| - The role of insulin resistance in the pathogenesis of cardiometabolic risk in diabetes mellitus (en)
- Význam insulinové resistence v patogenezi kardiometabolického rizika u diabetes mellitus
|
| skos:notation
| |
| http://linked.open...avai/cep/aktivita
| |
| http://linked.open...kovaStatniPodpora
| |
| http://linked.open...ep/celkoveNaklady
| |
| http://linked.open...datumDodatniDoRIV
| |
| http://linked.open...i/cep/druhSouteze
| |
| http://linked.open...ep/duvernostUdaju
| |
| http://linked.open.../cep/fazeProjektu
| |
| http://linked.open...ai/cep/hlavniObor
| |
| http://linked.open...vai/cep/kategorie
| |
| http://linked.open.../cep/klicovaSlova
| - Insulin resistance; diabetes mellitus type 1 and 2; modified fasting; substrate utilization; indirect calorimetry; glycemic clamp; body composition; endothelial dysfunction; cholesterol metabolism (en)
|
| http://linked.open...ep/partnetrHlavni
| |
| http://linked.open...inujicichPrijemcu
| |
| http://linked.open...cep/pocetPrijemcu
| |
| http://linked.open...ocetSpoluPrijemcu
| |
| http://linked.open.../pocetVysledkuRIV
| |
| http://linked.open...enychVysledkuVRIV
| |
| http://linked.open...lneniVMinulemRoce
| |
| http://linked.open.../prideleniPodpory
| |
| http://linked.open...iciPoslednihoRoku
| |
| http://linked.open...atUdajeProjZameru
| |
| http://linked.open.../vavai/cep/soutez
| |
| http://linked.open...usZobrazovaneFaze
| |
| http://linked.open...ai/cep/typPojektu
| |
| http://linked.open...ep/ukonceniReseni
| |
| http://linked.open...ep/zahajeniReseni
| |
| http://linked.open...tniCyklusProjektu
| |
| http://linked.open.../cep/klicoveSlovo
| - Insulin resistance
- endothelial dysfunction
- body composition
- diabetes mellitus type 1 and 2
- glycemic clamp
- indirect calorimetry
- modified fasting
- substrate utilization
|
| is http://linked.open...vavai/riv/projekt
of | |
| is http://linked.open...vavai/cep/projekt
of | |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)