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AttributesValues
rdf:type
rdfs:label
  • Litronesib
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Litronesib
NCI_META_CUI
  • CL413590
CAS_Registry
  • 910634-41-2
FDA_UNII_Code
  • 6611F8KYCV
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 661443
PDQ_Closed_Trial_Search_ID
  • 661443
Chemical_Formula
  • C23H37N5O4S2
FULL_SYN
  • Propanamide, N-[4-(2,2-dimethyl-1-oxopropyl)-5-[[[[2-(ethylamino)ethyl]sulfonyl] amino]methyl]-4,5-dihydro-5-phenyl-1,3,4-thiadiazol-2-yl]-2,2-dimethyl-, (-)-SNNCI
  • KF89617CNNCI
  • LITRONESIBPTFDA6611F8KYCV
  • LY2523355CNNCI
  • LitronesibPTNCI
DEFINITION
  • An inhibitor of the kinesin-related motor protein Eg5 with potential antineoplastic activity. Litronesib selectively inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and consequently cell death in tumor cells that are actively dividing. The ATP-dependent Eg5 kinesin-related motor protein (also known as KIF11 or kinesin spindle protein-5) is a plus-end directed kinesin motor protein that plays an essential role during mitosis, particularly in the regulation of spindle dynamics, including assembly and maintenance.NCI
code
  • C88328
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