About: Therapeutic Testosterone

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Therapeutic Testosterone
rdfs:subClassOf	Anabolic Steroid Therapeutic Androgen nodeID://b719384 nodeID://b719385 nodeID://b719386
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Is_Related_To_Endogenous_Product	Testosterone
Semantic_Type	Pharmacologic Substance Steroid
Preferred_Name	Therapeutic Testosterone
NSC_Code	9700
UMLS_CUI	C0039601
CAS_Registry	58-22-0
Accepted_Therapeutic_Use_For	Delayed puberty, male; Hypogonadism; Metastatic mammary cancer
In_Clinical_Trial_For	Breast cancer, prevention; Cachexia; Prostate cancer
FDA_UNII_Code	3XMK78S47O
Contributing_Source	FDA
PDQ_Open_Trial_Search_ID	42926
PDQ_Closed_Trial_Search_ID	42926
Chemical_Formula	C19H28O2
Legacy_Concept_Name	Therapeutic_Testosterone
CHEBI_ID	CHEBI:17347
FULL_SYN	TESTOSTERONEPTFDA3XMK78S47O VirosteroneFBNCI TestostrovalSYDTPNSC0017591 TestosteroneSYNCI TestostrovalBRNCI Therapeutic TestosteronePTNCI (17Beta)-17-hydroxyandrost-4-en-3-oneSNNCI Testostroval-PABRNCI TestosteronePTDCP00437 Trans-TestosteroneSYNCI TestolinBRNCI MertestateSYDTPNSC0009700 Testro AQBRNCI TestodermBRNCI Delta4-Androsten-17beta-ol-3-oneSNNCI MertestateFBNCI
DEFINITION	A synthetic form of the endogenous androgenic steroid testosterone. In vivo, testosterone is irreversibly converted to dihydrotestosterone (DHT) in target tissues by the enzyme 5-alpha reductase. Testosterone or DHT ligand-androgen receptor complexes act as transcription factor complexes, stimulating the expression of various responsive genes. DHT binds with higher affinity to androgen receptors than testosterone, activating gene expression more efficiently. In addition, testosterone is irreversibly converted to estradiol by the enzyme complex aromatase, particularly in the liver and adipose tissue. Testosterone and DHT promote the development and maintenance of male sex characteristics related to the internal and external genitalia, skeletal muscle, and hair follicles; estradiol promotes epiphyseal maturation and bone mineralization. Due to rapid metabolism by the liver, therapeutic testosterone is generally administered as an ester derivative.NCI
code	C862
sameAs	TESTOSTERONE TESTOSTERONE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0021196
is rdfs:subClassOf of	TESTOSTERONE CYPIONATE TESTOSTERONE ENANTHATE Testosterone Isobutyrate TESTOSTERONE UNDECANOATE Testosterone Gel Testosterone Vaginal Cream TESTOSTERONE PROPIONATE Testosterone Bucyclate Testosterone Phenylacetate
is sameAs of	TESTOSTERONE TESTOSTERONE TESTOSTERONE TESTOSTERONE

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