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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Testosterone Gel
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Testosterone Gel
UMLS_CUI
  • C0875960
Accepted_Therapeutic_Use_For
  • Hypogonadism -- Male
PDQ_Open_Trial_Search_ID
  • 589197
PDQ_Closed_Trial_Search_ID
  • 589197
Legacy_Concept_Name
  • Testosterone_Gel
FULL_SYN
  • Testosterone GelPTNCI
  • AndroGelBRNCI
  • FortestaBRNCI
DEFINITION
  • A topical gel preparation of synthetic testosterone. In vivo, testosterone is irreversibly converted to dihydrotestosterone (DHT) in target tissues by the enzyme 5-alpha reductase. Testosterone or DHT ligand-androgen receptor complexes act as transcription factor complexes, stimulating the expression of various responsive genes, resulting in an increase in protein anabolism, a decrease in amino acid catabolism, and retention of nitrogen, potassium, and phosphorus; DHT binds with higher affinity to nuclear androgen receptors than testosterone. In addition, testosterone is irreversibly converted to estradiol by the enzyme complex aromatase, particularly in the liver and adipose tissue. Testosterone and DHT promote the development and maintenance of male sex characteristics related to the internal and external genitalia, skeletal muscle, and hair follicles; estradiol promotes epiphyseal maturation and bone mineralization.NCI
code
  • C74081
http://linked.open...y/mesh/hasConcept
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