About: MET Tyrosine Kinase Inhibitor BMS-777607     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • MET Tyrosine Kinase Inhibitor BMS-777607
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • MET Tyrosine Kinase Inhibitor BMS-777607
UMLS_CUI
  • C2346911
PDQ_Open_Trial_Search_ID
  • 587999
PDQ_Closed_Trial_Search_ID
  • 587999
Legacy_Concept_Name
  • MET_Tyrosine_Kinase_Inhibitor_BMS-777607
FULL_SYN
  • MET Tyrosine Kinase Inhibitor BMS-777607PTNCI
  • BMS-777607CNNCI
DEFINITION
  • An inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibitor BMS-777607 binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway; this agent may induce cell death in tumor cells expressing c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and in tumor angiogenesis.NCI
code
  • C74060
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