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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Zinostatin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Antibiotic
Preferred_Name
  • Zinostatin
PubMedID_Primary_Reference
  • 20735485
NSC_Code
  • 157365
  • 69856
UMLS_CUI
  • C0027597
CAS_Registry
  • 9014-02-2
FDA_UNII_Code
  • PP082U6W1L
Contributing_Source
  • FDA
ALT_DEFINITION
  • An antitumor isolate from the culture filtrate of the F-41 variant of Streptomyces carzinostaticus. It is a protein of known amino acid sequence with a molecular weight of approximately 11,500 and possessing a regulatory function on the metabolism of DNA. In this process, that is first an inhibition of DNA biosynthesis followed by the degradation of DNA, zinostatin functions in a manner analogous to that of the much higher molecular weight antibiotic MITOMYCIN. Zinostatin is also a potent cytostatic agent active against gram-positive organisms.MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 39510
PDQ_Closed_Trial_Search_ID
  • 39510
Chemical_Formula
  • C35H35NO12
Legacy_Concept_Name
  • Zinostatin
FULL_SYN
  • VinostatinSYNCI
  • ZinostatinPTNCI
  • NCSABNCI
  • NeocarzinostatinSYNCI
  • ZINOSTATINPTFDAPP082U6W1L
  • HoloneocarzinostatinSYNCI
  • A 8544527G1CNNCI
DEFINITION
  • An enediyne antineoplastic antibiotic hybrid containing an aminoglycoside chromophore. Zinostatin is isolated from the bacterium Streptomyces carzinostaticus. The aminoglycoside component of zinostatin intercalates into DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-strand breaks in DNA and apoptosis. (NCI04)NCI
code
  • C682
sameAs
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