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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Penbutolol
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Penbutolol
UMLS_CUI
  • C0030812
CAS_Registry
  • 38363-40-5
FDA_UNII_Code
  • 78W62V43DY
Contributing_Source
  • FDA
Chemical_Formula
  • C18H29NO2
Legacy_Concept_Name
  • Penbutolol
CHEBI_ID
  • CHEBI:7954
FULL_SYN
  • PENBUTOLOLPTFDA78W62V43DY
  • PenbutololPTNCI
DEFINITION
  • A lipophilic, nonselective beta-adrenergic receptor antagonist with anti-anginal and antihypertensive activities. Penbutolol competitively binds to and blocks beta-1 adrenergic receptors in the heart, thereby decreasing cardiac contractility and rate. This leads to a reduction in cardiac output and lowers blood pressure. In addition, penbutolol prevents the release of renin, a hormone secreted by the kidneys that causes constriction of blood vessels.NCI
code
  • C66336
sameAs
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