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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Enalapril
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Enalapril
UMLS_CUI
  • C0014025
CAS_Registry
  • 75847-73-3
FDA_UNII_Code
  • 69PN84IO1A
Contributing_Source
  • FDA
ALT_DEFINITION
  • An antihypertensive agent that can also be used to slow or prevent the progression of heart disease in people with childhood cancer treated with drugs that may be harmful to the heart.NCI-GLOSS
Chemical_Formula
  • C20H28N2O5
Legacy_Concept_Name
  • Enalapril_Base
CHEBI_ID
  • CHEBI:4784
FULL_SYN
  • ENALAPRILPTFDA69PN84IO1A
  • EnalaprilPTNCI
  • enalaprilPTNCI-GLOSSCDR0000045508
DEFINITION
  • A dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.NCI
code
  • C62027
sameAs
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