About: Enalapril Maleate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Enalapril Maleate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Enalapril Maleate
UMLS_CUI
  • C0600128
CAS_Registry
  • 76095-16-4
FDA_UNII_Code
  • 9O25354EPJ
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 42544
PDQ_Closed_Trial_Search_ID
  • 42544
Chemical_Formula
  • C20H28N2O5.C4H4O4
Legacy_Concept_Name
  • Enalapril
CHEBI_ID
  • CHEBI:4785
FULL_SYN
  • Enalapril MaleatePTDCP32060
  • Enalapril MaleatePTNCI
  • ENALAPRIL MALEATEPTFDA9O25354EPJ
  • EnacardBRNCI
  • RenitecFBNCI
  • VasotecBRNCI
DEFINITION
  • The maleate salt form of enalapril, a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.NCI
code
  • C468
sameAs
http://linked.open...y/mesh/hasConcept
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