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AttributesValues
rdf:type
rdfs:label
  • Propoxyphene
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Propoxyphene
UMLS_CUI
  • C0033493
CAS_Registry
  • 469-62-5
FDA_UNII_Code
  • S2F83W92TK
Contributing_Source
  • FDA
Chemical_Formula
  • C22H29NO2
Legacy_Concept_Name
  • Propoxyphene
CHEBI_ID
  • CHEBI:51173
FULL_SYN
  • PROPOXYPHENEPTFDAS2F83W92TK
  • 4-Dimethylamino-3-methyl-1,2-diphenyl-2-propoxybutaneSNNCI
  • PropoxyphenePTNCI
  • d-PropoxypheneSYNCI
  • SK 65CNNCI
  • AlgafanBRNCI
  • FemadolBRNCI
  • DextropropoxypheneSYNCI
  • AntalvicBRNCI
  • ProxyvonBRNCI
  • ProxagesicBRNCI
DEFINITION
  • The d-isomer of synthetic diphenyl propionate derivative propoxyphene, with narcotic analgesic effect. This agent mimics the effects of the endogenous opiate dextropropoxyphene, by binding to mu receptors located throughout the central nervous system. The binding results in GTP to GDP exchanges on the mu-G-protein complex, by which effector adenylate cyclase is inactivated thereby decreasing intracellular cAMP. This, in turn, inhibits the release of various nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, noradrenaline, vasopressin, and somatostatin. In addition, dextropropoxyphene closes N-type voltage-gated calcium channels and opens calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization, thereby reducing neuronal excitability, which further decreases the perception of pain.NCI
code
  • C61912
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