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AttributesValues
rdf:type
rdfs:label
  • Oxiconazole
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Oxiconazole
UMLS_CUI
  • C0069765
CAS_Registry
  • 64211-45-6
FDA_UNII_Code
  • C668Q9I33J
Contributing_Source
  • FDA
Chemical_Formula
  • C18H13Cl4N3O
Legacy_Concept_Name
  • Oxiconazole
FULL_SYN
  • OxiconazolePTNCI
  • OXICONAZOLEPTFDAC668Q9I33J
DEFINITION
  • A broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole, like other azole antifungals, most likely inhibits the cytochrome P450-dependent demethylation of lanosterol. This prevents the synthesis of ergosterol which is a crucial component of fungal cell membrane. By disrupting fungal cell membrane synthesis and integrity, oxiconazole alters fungal cell membrane permeability, promotes loss of essential intracellular components and eventually inhibits fungal cell growth.NCI
code
  • C61869
sameAs
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