About: Oxiconazole Nitrate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Oxiconazole Nitrate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Oxiconazole Nitrate
UMLS_CUI
  • C0142160
CAS_Registry
  • 64211-46-7
FDA_UNII_Code
  • RQ8UL4C17S
Contributing_Source
  • FDA
Chemical_Formula
  • C18H13Cl4N3O.HNO3
Legacy_Concept_Name
  • Oxiconazole_Nitrate
FULL_SYN
  • OxistatBRNCI
  • Oxiconazole NitratePTNCI
  • Ethanone, 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-, O-((2,4-dichlorophenyl)methyl)oxime,(Z)-, MononitrateSNNCI
  • OXICONAZOLE NITRATEPTFDARQ8UL4C17S
  • (Z)-1-(2-(2,4-Dichlorophenyl)-2-(((2,4-dichlorophenyl)oxy)imino)ethyl)-1H-imidazole MononitrateSNNCI
DEFINITION
  • The nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole, like other azole antifungals, most likely inhibits the cytochrome P450-dependent demethylation of lanosterol. This prevents the synthesis of ergosterol which is a crucial component of fungal cell membrane. By disrupting fungal cell membrane synthesis and integrity, oxiconazole alters fungal cell membrane permeability, promotes loss of essential intracellular components and eventually inhibits fungal cell growth.NCI
code
  • C47644
sameAs
http://linked.open...y/mesh/hasConcept
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