About: Fowlpox-PSA-TRICOM Vaccine     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Fowlpox-PSA-TRICOM Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Virus
Preferred_Name
  • Fowlpox-PSA-TRICOM Vaccine
UMLS_CUI
  • C1327972
In_Clinical_Trial_For
  • Metastatic prostate cancer
Legacy_Concept_Name
  • Fowlpox-PSA-TRICOM_Vaccine
FULL_SYN
  • Fowlpox-PSA-TRICOM VaccinePTNCI
  • fPSA-TRIABNCI
DEFINITION
  • A cancer vaccine consisting of a recombinant fowlpox virus encoding human prostate-specific antigen (PSA) and TRICOM, a combination of three immunostimulants (i.e., B7.1, ICAM-1, and LFA-3). Administration of this agent may induce a cytotoxic T cell response against PSA-expressing tumor cells. Dendritic cells infected with TRICOM vectors greatly enhance naive T-cell activation and peptide-specific T-cell stimulation. Fowlpox virus is an attractive vector because its genome is easy to manipulate and it is replication incompetent in mammalian cells.NCI
code
  • C38708
is someValuesFrom of
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