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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Indapamide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Indapamide
UMLS_CUI
  • C0021186
CAS_Registry
  • 26807-65-8
FDA_UNII_Code
  • F089I0511L
Contributing_Source
  • FDA
Chemical_Formula
  • C16H16ClN3O3S
Legacy_Concept_Name
  • Indapamide
FULL_SYN
  • IndapamidePTDCP32078
  • LozolBRNCI
  • INDAPAMIDEPTFDAF089I0511L
  • IndapamidePTNCI
DEFINITION
  • An indole derivative of chlorosulphonamide and a sulfamyl diuretic with antihypertensive activity. Indapamide may interact directly with the subunits of delayed rectifier potassium channels, thereby blocking both slow and rapid K+ (IKs and IKr) currents through the channels. Through the homeostasis mechanism in balancing total ion concentration (Ca++, Na+), it reduces vascular hyperreactivity and peripheral and arterial vascular resistance, possibly by inhibiting transmembrane ionic influx, probably calcium ions, and stimulating prostaglandin E2 synthesis, thereby causing vasodilatation. Indapamide exerts its diuretic effect by inhibiting reabsorption of sodium and chloride, primarily as a result of action on the cortical diluting segment of the renal distal tubule, thereby promoting urinary excretion of water and electrolytes.NCI
code
  • C29119
sameAs
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