About: Ubiquitination

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Ubiquitination
rdfs:subClassOf	Post-Translational Modification nodeID://b722028
Semantic_Type	Molecular Function
Preferred_Name	Ubiquitination
UMLS_CUI	C1519751
Legacy_Concept_Name	Ubiquitination
FULL_SYN	Protein UbiquitinationSYNCI UbiquitilationSYNCI UbiquitinationPTNCI UbiquitinoylationSYNCI
DEFINITION	Ubiquitin is a family of widely distributed proteins found in all eukaryotes that contain a highly conserved sequence of 76 amino acids identical in organisms from humans to insects. It participates in diverse cellular functions by conjugation to other proteins through its carboxy terminus. Ubiquitination is associated with many highly regulated biological events including protein degradation, chromatin remodelling, heat shock, cell cycle progression, differentiation, antigen presentation, retrovirus assembly, apoptosis, signal transduction, transcriptional activation, biological clocks, receptor down regulation, and endocytosis. Protein ubiquitination regulates the half-lives of many proteins by targeting them for degradation. Newly discovered families of ubiquitination and deubiquitination enzymes participate in these processes. Ubiquitination enzymes may provide new therapeutic targets and ways of intervention in many human diseases.NCI
code	C19358
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0508560
is rdfs:subClassOf of	Polyubiquitination Monoubiquitination
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