About: Alvocidib Hydrochloride

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Attributes	Values
rdf:type	Class
rdfs:label	Alvocidib Hydrochloride
rdfs:subClassOf	Cyclin-Dependent Kinase Inhibitor nodeID://b673651 nodeID://b673652 nodeID://b673653 nodeID://b673654 nodeID://b673655 nodeID://b673656 nodeID://b673657
Has_Free_Acid_Or_Base_Form	Alvocidib
Has_Target	Cyclin-Dependent Kinases
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Alvocidib Hydrochloride
NSC_Code	649890
UMLS_CUI	C0281603
CAS_Registry	131740-09-5
In_Clinical_Trial_For	Breast cancer; Head and Neck cancer; Hematologic cancer; Hepatocellular carcinoma; Kidney and urinary cancer; Lymphoid cancer; ovarian epithelial cancer; Pancreatic cancer; Peritoneal cavity cancer; Thorax and respiratory cancer; Unspecified solid tumors
FDA_UNII_Code	D48MS3A6N9
Contributing_Source	FDA
ALT_DEFINITION	A substance being studied in the treatment of several types of cancer. It stops cells from dividing and may kill cancer cells. It is a type of cyclin-dependent kinase (CDK) inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID	42068
PDQ_Closed_Trial_Search_ID	42068
Chemical_Formula	C21H20ClNO5.HCl
Legacy_Concept_Name	Flavopiridol
FULL_SYN	MDL 107,826ACNNCI Alvocidib HydrochloridePTNCI ALVOCIDIB HYDROCHLORIDEPTFDAD48MS3A6N9 Flavopiridol HydrochlorideSYNCI 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5, 7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride, (-)-cis-SYDTPNSC0649890 HL-275CNNCI HMR 1275PTNCI-GLOSSCDR0000630914 L-868275CNNCI HMR 1275CNNCI L-86-8275CNNCI (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one HydrochlorideSNNCI MDL-107826ACNNCI
DEFINITION	A synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity.NCI
code	C1571
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0209200
is someValuesFrom of	nodeID://b657141 nodeID://b660262 nodeID://b660264 nodeID://b660267 nodeID://b664227 nodeID://b667144 nodeID://b673660 nodeID://b673661 nodeID://b673666 nodeID://b673668 nodeID://b673670 nodeID://b673673 nodeID://b673675 nodeID://b673676
is Has_Salt_Form of	Alvocidib

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