About: Dolastatin 10     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Dolastatin 10
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Dolastatin 10
NSC_Code
  • 376128
UMLS_CUI
  • C0082338
CAS_Registry
  • 110417-88-4
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. It binds to a protein that cells need to divide and it may kill cancer cells. Dolastatin 10 comes from a marine organism. It is a type of mitotic inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42316
PDQ_Closed_Trial_Search_ID
  • 42316
Legacy_Concept_Name
  • Dolastatin_10
FULL_SYN
  • Dolastatin 10SYDTPNSC0376128
  • Dolastatin 10PTNCI
  • Dolastatin-10SYNCI
  • dolastatin 10PTNCI-GLOSSCDR0000045452
  • B720389K560SYDTPNSC0376128
  • L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-, [2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]]SNNCI
  • B720389K560CNNCI
DEFINITION
  • A pentapeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Binding to tubulin, Dolastatin 10 inhibits microtubule assembly, resulting in the formation of tubulin aggregates and inhibition of mitosis. This agent also induces tumor cell apoptosis through a mechanism involving bcl-2, an oncoprotein that is overexpressed in some cancers. (NCI04)NCI
code
  • C1300
http://linked.open...y/mesh/hasConcept
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