About: KW-2149     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • KW-2149
rdfs:subClassOf
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • KW-2149
UMLS_CUI
  • C0064443
CAS_Registry
  • 118359-59-4
PDQ_Open_Trial_Search_ID
  • 42572
PDQ_Closed_Trial_Search_ID
  • 42572
Legacy_Concept_Name
  • KW-2149
FULL_SYN
  • 7-N-(2-((2-(gamma-L-Glutamylamino)ethyl)dithio)ethyl)mitomycin CSNNCI
  • KT6149CNNCI
  • KW 2149CNNCI
  • KW-2149PTNCI
DEFINITION
  • A semisynthetic water-soluble disulfide derivative of the antineoplastic antibiotic mitomycin C. Activated by serum and glutathione, KW-2149 causes interstrand DNA cross-links and DNA-protein cross-links, resulting in single-strand DNA breaks and inhibition of DNA synthesis. (NCI04)NCI
code
  • C1140
http://linked.open...y/mesh/hasConcept
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