About: Apaziquone     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Apaziquone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Apaziquone
NSC_Code
  • 382456
UMLS_CUI
  • C0095568
CAS_Registry
  • 114560-48-4
FDA_UNII_Code
  • H464ZO600O
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 42095
PDQ_Closed_Trial_Search_ID
  • 42095
Chemical_Formula
  • C15H16N2O4
Legacy_Concept_Name
  • EO9
FULL_SYN
  • EO9CNNCI
  • E O9SYNCI
  • 3-hydroxymethyl-5-aziridinyl-1-methyl-2-(1H-indole-4,7-dione) prop-beta-en-alpha-olSNNCI
  • EoquinBRNCI
  • NeoquinBRNCI
  • APAZIQUONEPTFDAH464ZO600O
  • ApaziquonePTNCI
DEFINITION
  • An indolequinone bioreductive prodrug and analog of mitomycin C with potential antineoplastic and radiosensitization activities. Apaziquone is converted to active metabolites in hypoxic cells by intracellular reductases, which are present in greater amounts in hypoxic tumor cells. The active metabolites alkylate DNA, resulting in apoptotic cell death. This agent displays selectivity activity towards both hypoxic solid tumors, which exhibits higher expression of cytochrome P450 reductase, and well-oxygenated malignant cells that overexpress the bioreductive enzyme NQO1 (NAD(P)H: quinone oxidoreductase). Apaziquone may selectively sensitize hypoxic tumor cells to radiocytotoxicity.NCI
code
  • C1087
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