About: AR Antagonist ODM-201     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • AR Antagonist ODM-201
rdfs:subClassOf
Has_Target
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • AR Antagonist ODM-201
PDQ_Open_Trial_Search_ID
  • 746231
PDQ_Closed_Trial_Search_ID
  • 746231
FULL_SYN
  • ODM-201CNNCI
  • Antiandrogen ODM-201SYNCI
  • AR Antagonist ODM-201PTNCI
DEFINITION
  • A formulation containing an androgen receptor (AR) antagonist with potential antineoplastic activity. AR antagonist ODM-201 binds to ARs in target tissues; subsequently, inhibiting androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes that regulate prostate cancer cell proliferation. This ultimately leads to an inhibition of growth in AR-expressing prostate cancer cells.NCI
code
  • C104748
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