About: Antineoplaston A10     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Antineoplaston A10
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Antineoplaston A10
NSC_Code
  • 377381
  • 619130
UMLS_CUI
  • C0052080
CAS_Registry
  • 91531-30-5
In_Clinical_Trial_For
  • Adrenal gland cancer; astrocytoma; brain tumor; breast cancer; colon cancer; ependymoma; esophageal cancer; glioblastoma multiforme; lung cancer; lymphoma; melanoma
  • Mesothelioma; multiple myeloma; neuroectodermal tumor; neuroendocrine tumor; pancreatic cancer; prostate cancer; rhabdoid tumor of the CNS
PDQ_Open_Trial_Search_ID
  • 41984
PDQ_Closed_Trial_Search_ID
  • 41984
Legacy_Concept_Name
  • Antineoplaston_A10
FULL_SYN
  • Antineoplaston A10PTDCP30663
  • Antineoplaston A10PTNCI
  • 3-Phenylacetylamino-2, 6-piperidinedioneSNNCI
  • 3-Phenylacetylamino-2,6-piperidinedioneSYDTPNSC0619130
DEFINITION
  • A piperidinedione antineoplaston with potential antineoplastic activity. Antineoplaston A10 was originally isolated from human urine but is now synthetically derived. This agent intercalates into DNA, resulting in cell cycle arrest in G1 phase, reduction of mitosis, and decreased protein synthesis. Antineoplaston A10 may also inhibit ras-oncogene expression and activate tumor suppressor gene p53, leading to cell differentiation and apoptosis. (NCI04)NCI
code
  • C1004
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