About: Discriminating adenocarcinoma from normal colonic mucosa through deconvolution of Raman spectra

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Feasibility of Raman spectroscopy for discriminating between adenocarcinomatous and normal mucosal formalin-fixed colonic tissues is considered. A spectral deconvolution model was used to derive spectral information. Samples of human colon were analyzed. Each spectrum was resolved into 25 bands from 975 to 1720 cm1, where modes of proteins, lipids, and nucleic acids are observed. From a comparative study of band intensities, the tissue types were correlated to biochemical assignments. Results used as inputs for linear discriminant analysis, yielding accuracies up to 81%. The bands with higher diagnosis relevance to confine the study to some spectral regions instead of broader ranges. A critical view upon limitations of this approach is presented. This enabled to assess the effect of formalin fixation in colonic tissues, and determine its relevance. Feasibility of Raman spectroscopy for discriminating between adenocarcinomatous and normal mucosal formalin-fixed colonic tissues is considered. A spectral deconvolution model was used to derive spectral information. Samples of human colon were analyzed. Each spectrum was resolved into 25 bands from 975 to 1720 cm1, where modes of proteins, lipids, and nucleic acids are observed. From a comparative study of band intensities, the tissue types were correlated to biochemical assignments. Results used as inputs for linear discriminant analysis, yielding accuracies up to 81%. The bands with higher diagnosis relevance to confine the study to some spectral regions instead of broader ranges. A critical view upon limitations of this approach is presented. This enabled to assess the effect of formalin fixation in colonic tissues, and determine its relevance. (en)
Title	Discriminating adenocarcinoma from normal colonic mucosa through deconvolution of Raman spectra Discriminating adenocarcinoma from normal colonic mucosa through deconvolution of Raman spectra (en)
skos:prefLabel	Discriminating adenocarcinoma from normal colonic mucosa through deconvolution of Raman spectra Discriminating adenocarcinoma from normal colonic mucosa through deconvolution of Raman spectra (en)
skos:notation	RIV/68378271:_____/11:00370442!RIV12-AV0-68378271
http://linked.open...avai/predkladatel	Fyzikální ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z10100520), Z(AV0Z10100521)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Gregora, Ivan Ledinský, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	194809
http://linked.open...ai/riv/idVysledku	RIV/68378271:_____/11:00370442
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	biomedical optics; Raman spectroscopy; deconvolution; data processing (en)
http://linked.open.../riv/klicoveSlovo	Raman spectroscopy data processing biomedical optics deconvolution
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[4E421CB95FAF]
http://linked.open...i/riv/nazevZdroje	Journal of Biomedical Optics
http://linked.open...in/vavai/riv/obor	BH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Almeida, A. Esteves, A. Gregora, Ivan Henrique, R. Ledinský, Martin Lopes, J. C. Lopes, P. C. Moreira, J. A Oliveira, A.
http://linked.open...ain/vavai/riv/wos	000299490300026
http://linked.open...n/vavai/riv/zamer	Specific effects in condensed systems with reduced dimension and broken symmetry Physics and technology of nanostructures, surfaces and thin films
issn	1083-3668
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1117/1.3658756
is http://linked.open...avai/riv/vysledek of	Discriminating adenocarcinoma from normal colonic mucosa through deconvolution of Raman spectra Discriminating adenocarcinoma from normal colonic mucosa through deconvolution of Raman spectra

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