About: Carborane-based carbonic anhydrase inhibitors

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	CA inhibitors: Human carbonic anhydrases (CAs) are diagnostic and therapeutic targets. Various carborane cages are shown to act as active-site-directed inhibitors, and substitution with a sulfamide group and other substituents leads to compounds with high selectivity towards the cancer-specific isozyme IX. Crystal structures of the carboranes in the active site provide information that can be applied to the structure-based design of specific inhibitors. CA inhibitors: Human carbonic anhydrases (CAs) are diagnostic and therapeutic targets. Various carborane cages are shown to act as active-site-directed inhibitors, and substitution with a sulfamide group and other substituents leads to compounds with high selectivity towards the cancer-specific isozyme IX. Crystal structures of the carboranes in the active site provide information that can be applied to the structure-based design of specific inhibitors. (en)
Title	Carborane-based carbonic anhydrase inhibitors Carborane-based carbonic anhydrase inhibitors (en)
skos:prefLabel	Carborane-based carbonic anhydrase inhibitors Carborane-based carbonic anhydrase inhibitors (en)
skos:notation	RIV/68378050:_____/13:00422652!RIV14-AV0-68378050
http://linked.open...avai/predkladatel	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(IAAX00320901), P(TE01020028)
http://linked.open...iv/cisloPeriodika	51
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Brynda, Jiří Fábry, Milan Mader, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	64271
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/13:00422652
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	carbonic anhydrases; carboranes; drug discovery; inhibitors; structure elucidation (en)
http://linked.open.../riv/klicoveSlovo	inhibitors structure elucidation drug discovery carbonic anhydrases carboranes
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[9288E7A4B300]
http://linked.open...i/riv/nazevZdroje	Angewandte Chemie. International Edition in English
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Functionalized boron clusters as viral enzyme inhihitors Center for Development of Original Drugs
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	52
http://linked.open...iv/tvurceVysledku	Brynda, Jiří Bakardjiev, Mario Cígler, Petr Fábry, Milan Grüner, Bohumír Řezáčová, Pavlína Mader, Pavel Šícha, Václav Poncová, Kristýna
http://linked.open...ain/vavai/riv/wos	000328437200054
issn	1433-7851
number of pages	4 (xsd:int)

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