About: Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Glial tumors exhibit a high morbidity and mortality because of their invasive nature. Matrix metalloproteinase 19 (MMP19) is a secreted protease that together with epilysin (MMP28) forms a structural subgroup of MMPs. In contrast, MMP19 was detected in normal brain samples only in endothelial cells but was found at high levels in astrocytomas. MMP19 was upregulated in GB cells after exposure to proinflammatory cytokines. MMP19-silenced cells migrated more slowly through laminin-, basal lamina-, and brevican-coated membranes than controls. MMP19-silenced GB cells also migrated into brain tissue slices compared with control cells. Brevican, a brain-specific proteoglycan and major component of brain extracellular matrix, was degraded by recombinant human MMP19. MMP19 is highly expressed in proliferating astrocytoma/glioma cells and its expression may facilitate their invasion through brain extracellular matrix Glial tumors exhibit a high morbidity and mortality because of their invasive nature. Matrix metalloproteinase 19 (MMP19) is a secreted protease that together with epilysin (MMP28) forms a structural subgroup of MMPs. In contrast, MMP19 was detected in normal brain samples only in endothelial cells but was found at high levels in astrocytomas. MMP19 was upregulated in GB cells after exposure to proinflammatory cytokines. MMP19-silenced cells migrated more slowly through laminin-, basal lamina-, and brevican-coated membranes than controls. MMP19-silenced GB cells also migrated into brain tissue slices compared with control cells. Brevican, a brain-specific proteoglycan and major component of brain extracellular matrix, was degraded by recombinant human MMP19. MMP19 is highly expressed in proliferating astrocytoma/glioma cells and its expression may facilitate their invasion through brain extracellular matrix (en)
Title	Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells (en)
skos:prefLabel	Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells (en)
skos:notation	RIV/68378050:_____/10:00346779!RIV11-AV0-68378050
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Sedláček, Radislav Brauer, Rena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	269928
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/10:00346779
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	extracellular matrix; MMP-28; keratinocytes (en)
http://linked.open.../riv/klicoveSlovo	keratinocytes extracellular matrix MMP-28
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[4F6C8CB940A2]
http://linked.open...i/riv/nazevZdroje	Journal of Neuropathology and Experimental Neurology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	69
http://linked.open...iv/tvurceVysledku	Sedláček, Radislav Brauer, Rena Hattermann, K. Held-Feindt, J. Lettau, I. Mentlein, R.
http://linked.open...ain/vavai/riv/wos	000275418600001
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0022-3069
number of pages	9 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells

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