About: Genomic analysis of HIV type 1 strains derived from a mother and child pair of long-term nonprogressors

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Při dlouhotrvající infekci virem HIV-1 bez projevu onemocnění byly u matky a jejího dítěte zjišťovány rozdíly v genomu infikujících virů. Bylo zjištěno, že u prověřovaných kmenů nedošlo ke změnám, které by oslabily jejich účinnost a že atenuace onemocnění je způsobena pravděpodobně interakcí virů a imunitního systemu hostitele. (cs) To investigate the viral features of long-term nonprogressive HIV-1 infection and the selection of viral genomes, we studied serial complete HIV-1 sequences obtained from a mother-child pair, both long-term nonprogressors. Analysis of four genomic sequences demonstrated that all viral genes were intact, lacking major deletions or premature stop codons to easily explain the slow disease progression. These data suggest that viral attenuation, if present, was caused by subtle sequence variations or virus-host interactions. We demonstrated that the daughter's strains were most likely subjected to immunoselection or immunoediting according to the presence of novel MHC class I alleles that differed between mother and daughter. An analysis of nef-specific cytotoxic T-lymphocyte responses in the child, whose HIV-1 nef sequence differed from the maternal nef, supported this interpretation. To investigate the viral features of long-term nonprogressive HIV-1 infection and the selection of viral genomes, we studied serial complete HIV-1 sequences obtained from a mother-child pair, both long-term nonprogressors. Analysis of four genomic sequences demonstrated that all viral genes were intact, lacking major deletions or premature stop codons to easily explain the slow disease progression. These data suggest that viral attenuation, if present, was caused by subtle sequence variations or virus-host interactions. We demonstrated that the daughter's strains were most likely subjected to immunoselection or immunoediting according to the presence of novel MHC class I alleles that differed between mother and daughter. An analysis of nef-specific cytotoxic T-lymphocyte responses in the child, whose HIV-1 nef sequence differed from the maternal nef, supported this interpretation. (en)
Title	Genomic analysis of HIV type 1 strains derived from a mother and child pair of long-term nonprogressors Genomic analysis of HIV type 1 strains derived from a mother and child pair of long-term nonprogressors (en) Genová analýza HIV-1 virových kmenů izolovaných od matky a jejího dítěte, dlouhodobě non-progresorů (cs)
skos:prefLabel	Genomic analysis of HIV type 1 strains derived from a mother and child pair of long-term nonprogressors Genomic analysis of HIV type 1 strains derived from a mother and child pair of long-term nonprogressors (en) Genová analýza HIV-1 virových kmenů izolovaných od matky a jejího dítěte, dlouhodobě non-progresorů (cs)
skos:notation	RIV/68378050:_____/07:00091832!RIV08-AV0-68378050
http://linked.open.../vavai/riv/strany	309;315
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Reiniš, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	423203
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/07:00091832
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HIV-1; genomic analysis (en)
http://linked.open.../riv/klicoveSlovo	HIV-1 genomic analysis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E878DBD74C8E]
http://linked.open...i/riv/nazevZdroje	Aids Research and Human Retroviruses
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Reiniš, Milan Zhang, Y. Lang, D. Burger, H. Weiser, B. Dong, T. Kuiken, C. Nachman, S. Rowland-Jones, S.
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0889-2229
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Genomic analysis of HIV type 1 strains derived from a mother and child pair of long-term nonprogressors Genomic analysis of HIV type 1 strains derived from a mother and child pair of long-term nonprogressors Genomic analysis of HIV type 1 strains derived from a mother and child pair of long-term nonprogressors

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