About: Diabetes and thyroid hormones affect connexin-43 and PKC-ε expression in rat heart atria

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cx43 expression was significantly increased after the treatment with T3 and in the acute diabetes. Both in diabetes and after T3 treatment the phosphorylation ofCx43 isoforms was markedly suppressed compared to the nondiabetic and T3-untreated controls. Such a down-regulation was less pronounced in diabetic rats after the T3-treatment. The expression of atrial PKC-ε was increased in diabetic rats. This increase was suppressed after T3 administration and the expression was decreased in T3-treated non-diabetic rats. We suggest that the reduced Cx43 phosphorylation in diabetic and hyperthyroid rats can deteriorate a cell-to-cell coupling and consequently facilitate a development of atrial tachyarrhythmia in diabetic or hyperthyroid animals Cx43 expression was significantly increased after the treatment with T3 and in the acute diabetes. Both in diabetes and after T3 treatment the phosphorylation ofCx43 isoforms was markedly suppressed compared to the nondiabetic and T3-untreated controls. Such a down-regulation was less pronounced in diabetic rats after the T3-treatment. The expression of atrial PKC-ε was increased in diabetic rats. This increase was suppressed after T3 administration and the expression was decreased in T3-treated non-diabetic rats. We suggest that the reduced Cx43 phosphorylation in diabetic and hyperthyroid rats can deteriorate a cell-to-cell coupling and consequently facilitate a development of atrial tachyarrhythmia in diabetic or hyperthyroid animals (en)
Title	Diabetes and thyroid hormones affect connexin-43 and PKC-ε expression in rat heart atria Diabetes and thyroid hormones affect connexin-43 and PKC-ε expression in rat heart atria (en)
skos:prefLabel	Diabetes and thyroid hormones affect connexin-43 and PKC-ε expression in rat heart atria Diabetes and thyroid hormones affect connexin-43 and PKC-ε expression in rat heart atria (en)
skos:notation	RIV/67985823:_____/09:00338071!RIV10-MSM-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA304/05/0327), P(GA304/08/0256), P(LC554), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Soukup, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	310133
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/09:00338071
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	diabetes; triiodothyronine; atrial fibrillation (en)
http://linked.open.../riv/klicoveSlovo	triiodothyronine atrial fibrillation diabetes
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[F7519AB3ADA6]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Regulation of muscle phenotype under normal, experimental and pathological conditions Neuroscience Centre Influence of thyroid hormones on expression of myofibrillar and Ca2+ transporting proteins
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	58
http://linked.open...iv/tvurceVysledku	Soukup, Tomáš Tribulová, N. Lin, H. Imanaga, I. Mitašíková, M.
http://linked.open...ain/vavai/riv/wos	265853100007
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0862-8408
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Diabetes and thyroid hormones affect connexin-43 and PKC-ε expression in rat heart atria Diabetes and thyroid hormones affect connexin-43 and PKC-ε expression in rat heart atria Diabetes and thyroid hormones affect connexin-43 and PKC-ε expression in rat heart atria Diabetes and thyroid hormones affect connexin-43 and PKC-ε expression in rat heart atria

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