Attributes | Values |
---|
rdf:type
| |
Description
| - Simple solid-phase synthesis of 3,10-dihydro-2H-benzo[e]imidazothiadiazin-2-one 5,5-dioxides is described, with Fmoc-?-amino acids and 2-nitrobenzenesulfonylchlorides (2-NosCls) being the key building blocks. Fmoc-?-amino acids were immobilized on Wang resin and transformed to the corresponding 2-nitrobenzenesulfonamides in two steps. After reduction of the nitro group, Fmoc-thioureas were synthesized followed by cyclization of the 1,2,4-benzothiadiazine-1,1-dioxide scaffold with diisopropylcarbodiimide (DIC). Cleavage of the Fmoc protecting group followed by spontaneous cyclative cleavage gave the target products in excellent crude purity.
- Simple solid-phase synthesis of 3,10-dihydro-2H-benzo[e]imidazothiadiazin-2-one 5,5-dioxides is described, with Fmoc-?-amino acids and 2-nitrobenzenesulfonylchlorides (2-NosCls) being the key building blocks. Fmoc-?-amino acids were immobilized on Wang resin and transformed to the corresponding 2-nitrobenzenesulfonamides in two steps. After reduction of the nitro group, Fmoc-thioureas were synthesized followed by cyclization of the 1,2,4-benzothiadiazine-1,1-dioxide scaffold with diisopropylcarbodiimide (DIC). Cleavage of the Fmoc protecting group followed by spontaneous cyclative cleavage gave the target products in excellent crude purity. (en)
|
Title
| - Solid-Phase Synthesis of Anagrelide Sulfonyl Analogues
- Solid-Phase Synthesis of Anagrelide Sulfonyl Analogues (en)
|
skos:prefLabel
| - Solid-Phase Synthesis of Anagrelide Sulfonyl Analogues
- Solid-Phase Synthesis of Anagrelide Sulfonyl Analogues (en)
|
skos:notation
| - RIV/61989592:15110/14:33151916!RIV15-MSM-15110___
|
http://linked.open...avai/riv/aktivita
| |
http://linked.open...avai/riv/aktivity
| - I, P(ED0030/01/01), P(EE2.3.20.0009), P(EE2.4.31.0130)
|
http://linked.open...iv/cisloPeriodika
| |
http://linked.open...vai/riv/dodaniDat
| |
http://linked.open...aciTvurceVysledku
| |
http://linked.open.../riv/druhVysledku
| |
http://linked.open...iv/duvernostUdaju
| |
http://linked.open...titaPredkladatele
| |
http://linked.open...dnocenehoVysledku
| |
http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/14:33151916
|
http://linked.open...riv/jazykVysledku
| |
http://linked.open.../riv/klicovaSlova
| - Cyclative cleavage; Solid-phase synthesis; 2-Nitrobenzenesulfonylchlorides; Fmoc-amino acids; Cyclic guanidines; Anagrelide analogues (en)
|
http://linked.open.../riv/klicoveSlovo
| |
http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
http://linked.open...ontrolniKodProRIV
| |
http://linked.open...i/riv/nazevZdroje
| - ACS Combinatorial Science
|
http://linked.open...in/vavai/riv/obor
| |
http://linked.open...ichTvurcuVysledku
| |
http://linked.open...cetTvurcuVysledku
| |
http://linked.open...vavai/riv/projekt
| |
http://linked.open...UplatneniVysledku
| |
http://linked.open...v/svazekPeriodika
| |
http://linked.open...iv/tvurceVysledku
| - Soural, Miroslav
- Popa, Igor
- Grepl, M.
- Fülöpová, Veronika
- Mcmaster, Claire Suzanne
|
issn
| |
number of pages
| |
http://localhost/t...ganizacniJednotka
| |