About: Cell-Cycle Regulation in Embryonic Stem Cells: Centrosomal Decisions on Self-Renewal.     Goto   Sponge   Distinct   Permalink

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  • Embryonic stem cells seem to have the intriguing capacity to divide indefinitely while retaining their pluripotency. This self-renewal is accomplished by specialized mechanisms of cell-cycle control. In the last few years, several studies have provided evidence for a direct link between cell-cycle regulation and cell-fate decisions in stem cells. In this review, we discuss the peculiarities of embryonic stem cell-cycle control mechanisms, implicate their involvement in cell-fate decisions, and distinguish centrosomes as important players in the self-renewal versus differentiation roulette.
  • Embryonic stem cells seem to have the intriguing capacity to divide indefinitely while retaining their pluripotency. This self-renewal is accomplished by specialized mechanisms of cell-cycle control. In the last few years, several studies have provided evidence for a direct link between cell-cycle regulation and cell-fate decisions in stem cells. In this review, we discuss the peculiarities of embryonic stem cell-cycle control mechanisms, implicate their involvement in cell-fate decisions, and distinguish centrosomes as important players in the self-renewal versus differentiation roulette. (en)
Title
  • Cell-Cycle Regulation in Embryonic Stem Cells: Centrosomal Decisions on Self-Renewal.
  • Cell-Cycle Regulation in Embryonic Stem Cells: Centrosomal Decisions on Self-Renewal. (en)
skos:prefLabel
  • Cell-Cycle Regulation in Embryonic Stem Cells: Centrosomal Decisions on Self-Renewal.
  • Cell-Cycle Regulation in Embryonic Stem Cells: Centrosomal Decisions on Self-Renewal. (en)
skos:notation
  • RIV/61989592:15110/10:10211952!RIV11-MSM-15110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(2B06077), Z(MSM6198959205)
http://linked.open...iv/cisloPeriodika
  • 11
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 249832
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/10:10211952
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • centrosome; cell cycle; embryonic stem cells (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [A4971D21EA0A]
http://linked.open...i/riv/nazevZdroje
  • Stem Cells and Development
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 19
http://linked.open...iv/tvurceVysledku
  • Krämer, Alwin
  • Divoký, Vladimír
  • Rašková Kafková, Leona
  • Koledová, Zuzana
http://linked.open...n/vavai/riv/zamer
issn
  • 1547-3287
number of pages
http://localhost/t...ganizacniJednotka
  • 15110
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