About: Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: a step forward

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Surfactant-free PLGA polymeric nanoparticles (PNPs) with hydrodynamic radius (RH) ranging from 25.8 nm to 128.5 nm were successfully obtained through nanoprecipitation by controlling a variety of physicochemical parameters. The size of the generated PLGA PNPs could be controlled by adjusting the polymer concentration, the choice of organic solvent, mixing different organic solvents or by changing temperature and ionic strength. By optimizing such parameters sub-100 nm uniform PNPs can be produced through this methodology including the advantage and ability to scale-up production. The PNPs have shown a size-dependent effect on the organic solvent and polymer concentration. On the other hand, the polymer–solvent interactions seem not to play a substantial role in the final dimension of the polymer colloids. It has been also evidenced that the size of PNPs can be precisely and linearly tuned by using solvent mixtures as organic phase. Surfactant-free PLGA polymeric nanoparticles (PNPs) with hydrodynamic radius (RH) ranging from 25.8 nm to 128.5 nm were successfully obtained through nanoprecipitation by controlling a variety of physicochemical parameters. The size of the generated PLGA PNPs could be controlled by adjusting the polymer concentration, the choice of organic solvent, mixing different organic solvents or by changing temperature and ionic strength. By optimizing such parameters sub-100 nm uniform PNPs can be produced through this methodology including the advantage and ability to scale-up production. The PNPs have shown a size-dependent effect on the organic solvent and polymer concentration. On the other hand, the polymer–solvent interactions seem not to play a substantial role in the final dimension of the polymer colloids. It has been also evidenced that the size of PNPs can be precisely and linearly tuned by using solvent mixtures as organic phase. (en)
Title	Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: a step forward Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: a step forward (en)
skos:prefLabel	Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: a step forward Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: a step forward (en)
skos:notation	RIV/61389013:_____/13:00399466!RIV14-GA0-61389013
http://linked.open...avai/predkladatel	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GA202/09/2078)
http://linked.open...iv/cisloPeriodika	5 September
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Štěpánek, Petr Jäger, Alessandro Jäger, Eliezer
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	96193
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/13:00399466
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	sub-100 nm polymeric nanoparticles; light scattering; nanoprecipitation (en)
http://linked.open.../riv/klicoveSlovo	nanoprecipitation sub-100 nm polymeric nanoparticles light scattering
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[2B2583CAB4EC]
http://linked.open...i/riv/nazevZdroje	Colloids and Surfaces. A - Physicochemical and Engineering Aspects
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Bioinspired nanoparticles sensitive to environment stimuli
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	436
http://linked.open...iv/tvurceVysledku	Štěpánek, Petr Giacomelli, F. C. Jäger, Alessandro Jäger, Eliezer de Oliveira, A. M.
http://linked.open...ain/vavai/riv/wos	000326416900135
issn	0927-7757
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.colsurfa.2013.08.056

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