About: Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Glycosyl 1,2,3-triazoles with a-D-gluco, b-D-gluco, a-D-galacto, b-D-galacto and b-2-acetamido-2-deoxygluco (GlcNAc) stereochemistry were prepared by reaction of the corresponding azides with vinyl acetate under microwave irradiation. The deprotected glucosyl and galactosyl triazoles did not display inhibitory activity against the tested glycosidases at 1 mM. Of the four fungal glycosidases evaluated, GlcNAc-triazole was found to be hydrolyzed by Talaromyces flavus CCF 2686 b-N-acetylhexosaminidase. β-GlcNActriazole was furthermore established to act as a strong ligand of rat and human natural killer cell activating receptors Glycosyl 1,2,3-triazoles with a-D-gluco, b-D-gluco, a-D-galacto, b-D-galacto and b-2-acetamido-2-deoxygluco (GlcNAc) stereochemistry were prepared by reaction of the corresponding azides with vinyl acetate under microwave irradiation. The deprotected glucosyl and galactosyl triazoles did not display inhibitory activity against the tested glycosidases at 1 mM. Of the four fungal glycosidases evaluated, GlcNAc-triazole was found to be hydrolyzed by Talaromyces flavus CCF 2686 b-N-acetylhexosaminidase. β-GlcNActriazole was furthermore established to act as a strong ligand of rat and human natural killer cell activating receptors (en)
Title	Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles (en)
skos:prefLabel	Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles (en)
skos:notation	RIV/61388971:_____/10:00348175!RIV11-GA0-61388971
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GD305/09/H008), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	14
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Slámová, Kristýna Křen, Vladimír Marhol, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	291458
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/10:00348175
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	glycosidase inhibition; beta-N-Acetylhexosaminidase; N-Glycoside (en)
http://linked.open.../riv/klicoveSlovo	N-Glycoside glycosidase inhibition beta-N-Acetylhexosaminidase
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[27BFD65FEA49]
http://linked.open...i/riv/nazevZdroje	Bioorganic and Medicinal Chemistry Letters
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Preparation, biotransformation, and optimalization of compounds with antitumor and antimicrobial effects
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Křen, Vladimír Slámová, Kristýna Jensen, H. H. Marhol, Petr Bezouška, K. Hansen, G. S. Lindkvist, L.
http://linked.open...ain/vavai/riv/wos	000279258800061
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0960-894X
number of pages	3 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles

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