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rdf:type
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Description
| - However cytostatic polymeric conjugates based on N-(2-hydroxypropyl)methacrylamide are in clinical trials, we are still far away from understanding the mechanism of their action. Cleavability of the drug from oligopeptidic side-chains of polymeric carriers seems not to be necessary condition for pharmacological activity and those spacers play most probably a very important role in the accumulation of conjugates in tumor cells.
- However cytostatic polymeric conjugates based on N-(2-hydroxypropyl)methacrylamide are in clinical trials, we are still far away from understanding the mechanism of their action. Cleavability of the drug from oligopeptidic side-chains of polymeric carriers seems not to be necessary condition for pharmacological activity and those spacers play most probably a very important role in the accumulation of conjugates in tumor cells. (en)
- Ačkoliv cytostatické polymerní konjugáty na bázi N-(2-hydroxypropyl)metakrylamidu jsou již ve fázi preklinických testů, skutečný mechanismus jejich účinku není ještě zcela objasněn. Zdá se že štěpitelnost postranních peptidických řetězců nesoucích cytostatikum není podmínkou účinnosti těchto konjugátů a tyto řetězce jsou zodpovědné spíše za masivní akumulaci těchto léčiv v nádorových buňkách. (cs)
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Title
| - Mechanism of action of HPMA-based non-targeted polymeric prodrugs
- Mechanism of action of HPMA-based non-targeted polymeric prodrugs (en)
- Mechanismus působení polymerních léčiv na bázi HPMA (cs)
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skos:prefLabel
| - Mechanism of action of HPMA-based non-targeted polymeric prodrugs
- Mechanism of action of HPMA-based non-targeted polymeric prodrugs (en)
- Mechanismus působení polymerních léčiv na bázi HPMA (cs)
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skos:notation
| - RIV/61388971:_____/04:00108060!RIV/2005/AV0/A53005/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388971:_____/04:00108060
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - hpma-dox; hpma-based (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...v/mistoKonaniAkce
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http://linked.open...i/riv/mistoVydani
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http://linked.open...i/riv/nazevZdroje
| - International Conference on Tumor Microenvironment:Progression, Therapy and Prevention /3./
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Etrych, Tomáš
- Strohalm, Jiří
- Ulbrich, Karel
- Říhová, Blanka
- Šubr, Vladimír
- Bouček, Jan
- Hovorka, Ondřej
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http://linked.open...vavai/riv/typAkce
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http://linked.open.../riv/zahajeniAkce
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http://linked.open...n/vavai/riv/zamer
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number of pages
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http://purl.org/ne...btex#hasPublisher
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