About: CycloSal-Phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-Deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases     Goto   Sponge   Distinct   Permalink

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Description
  • A series of cycloSal-phosphate prodrugs of a recently described new class of nucleoside cytostatics (6-hetaryl-7-deazapurine ribonucleosides) was prepared. The in vitro cytostatic effect of the pronucleotides was compared with parent nucleoside analogues. In most cases, the activity of the pronucleotide was similar to or somewhat lower than that of the corresponding parent nucleosides.
  • A series of cycloSal-phosphate prodrugs of a recently described new class of nucleoside cytostatics (6-hetaryl-7-deazapurine ribonucleosides) was prepared. The in vitro cytostatic effect of the pronucleotides was compared with parent nucleoside analogues. In most cases, the activity of the pronucleotide was similar to or somewhat lower than that of the corresponding parent nucleosides. (en)
Title
  • CycloSal-Phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-Deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases
  • CycloSal-Phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-Deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases (en)
skos:prefLabel
  • CycloSal-Phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-Deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases
  • CycloSal-Phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-Deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases (en)
skos:notation
  • RIV/61388963:_____/10:00350071!RIV11-MSM-61388963
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0508), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 8
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 252608
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/10:00350071
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • nucleosides; pronucleotides; deazapurines; cytostatics (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [77B66950586D]
http://linked.open...i/riv/nazevZdroje
  • ChemMedChem
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 5
http://linked.open...iv/tvurceVysledku
  • Hocek, Michal
  • Pichová, Iva
  • Pohl, Radek
  • Votruba, Ivan
  • Zábranská, Helena
  • Birkuš, G.
  • Nauš, Petr
  • Snášel, Jan
  • Spáčilová, Pavla
  • Ameral, R.
  • Cihlař, T.
http://linked.open...ain/vavai/riv/wos
  • 000281061300023
http://linked.open...n/vavai/riv/zamer
issn
  • 1860-7179
number of pages
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