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Description
| - DNA methylation inhibitors are being extensively studied as potential anticancer agents. In the present study, we compared the capability of alpha anomer of 5-aza-2'-deoxycytidine(alpha-5-azadCyd) to induce down-regulation of hTERT expression in HL-60 cells with other nucleoside analogs that act as DNA methylation inhibitors: beta-5-azadCyd (decitabine), (S)-9-(2,3-dihydroxypropyl)adenine [(S)-DHPA], isobutyl ester of (R,S)-3-(adenin-9-yl)-2-hydroxypropanoic acid [(R,S)-AHPA-ibu] and prospective DNA methylation inhibitors (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine [(S)-HPMPazaC] and 5-fluoro-zebularine (F-PymRf).
- DNA methylation inhibitors are being extensively studied as potential anticancer agents. In the present study, we compared the capability of alpha anomer of 5-aza-2'-deoxycytidine(alpha-5-azadCyd) to induce down-regulation of hTERT expression in HL-60 cells with other nucleoside analogs that act as DNA methylation inhibitors: beta-5-azadCyd (decitabine), (S)-9-(2,3-dihydroxypropyl)adenine [(S)-DHPA], isobutyl ester of (R,S)-3-(adenin-9-yl)-2-hydroxypropanoic acid [(R,S)-AHPA-ibu] and prospective DNA methylation inhibitors (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine [(S)-HPMPazaC] and 5-fluoro-zebularine (F-PymRf). (en)
- Inhibitory DNA metylace jsou studovány jako slibná protinádorová léčiva. V této práci srovnáváme schopnost alfa anomeru 5-aza-2'-deoxycytidinu(alfa-5-azadCyd) potlačit expresi telomerázy, enzymu, jehož zvýšená exprese je prokazatelná až u 90 % maligních nádorů, s ostatními analogy nukleosidů majícími hypometylační účinky: beta-5-azadCyd (decitabin), (S)-9-(2,3-dihydroxypropyl)adenin [(S)-DHPA], izobutyl ester (R,S)-3-(adenin-9-yl)-2-hydroxypropanové kyseliny [(R,S)-AHPA-ibu] a perspektivních inhibitorů DNA metylace (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosinu [(S)-HPMPazaC] and 5-fluoro-zebularinu (F-PymRf). (cs)
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Title
| - Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells
- Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells (en)
- Alfa anomer 5-aza-2'-deoxycytidinu snižuje expresi hTERT mRNA expression v lidských leukemických buňkách HL-60 (cs)
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skos:prefLabel
| - Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells
- Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells (en)
- Alfa anomer 5-aza-2'-deoxycytidinu snižuje expresi hTERT mRNA expression v lidských leukemických buňkách HL-60 (cs)
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skos:notation
| - RIV/61388963:_____/08:00305805!RIV08-AV0-61388963
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1M0508), P(1QS400550501), Z(AV0Z40550506)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388963:_____/08:00305805
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - alpha-5-aza-2'-deoxycytidine; DNA hypomethylation; hTERT; c-myc (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Holý, Antonín
- Krečmerová, Marcela
- Votruba, Ivan
- Tloušťová, Eva
- Hájek, Miroslav
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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is http://linked.open...avai/riv/vysledek
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