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rdf:type
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Description
| - Acetylcholinesterase (AChE; EC 3.1.1.7) reactivators are used as a part of the antidotes aimed for the treatment of organophosphorus pesticide and nerve agent intoxications. Cyclosarin is one member of the nerve agent family. In this work, we are interested in the comparison of reactivation potency of five structurally different AChE reactivators (pralidoxime, trimedoxime, methoxime, HS-6 and BI-6) to reactivate cyclosarin-inhibited cholinesterases of human brain. As resulted, bisquaternary monooxime reactivator BI-6 seems to be the most potent reactivator of cyclosarin-inhibited cholinesterases. Moreover, according to the obtained results, we can describe basic structural requirements, which are necessary for the efficacious reactivation process.
- Acetylcholinesterase (AChE; EC 3.1.1.7) reactivators are used as a part of the antidotes aimed for the treatment of organophosphorus pesticide and nerve agent intoxications. Cyclosarin is one member of the nerve agent family. In this work, we are interested in the comparison of reactivation potency of five structurally different AChE reactivators (pralidoxime, trimedoxime, methoxime, HS-6 and BI-6) to reactivate cyclosarin-inhibited cholinesterases of human brain. As resulted, bisquaternary monooxime reactivator BI-6 seems to be the most potent reactivator of cyclosarin-inhibited cholinesterases. Moreover, according to the obtained results, we can describe basic structural requirements, which are necessary for the efficacious reactivation process. (en)
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Title
| - Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin
- Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin (en)
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skos:prefLabel
| - Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin
- Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin (en)
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skos:notation
| - RIV/60162694:G44__/07:00001804!RIV10-MO0-G44_____
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/07:00001804
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - cholinesterase; reactivators; cyclosarin; nerve agent; oxime (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Cabal, Jiří
- Hrabinová, Martina
- Kuča, Kamil
- Jun, Daniel
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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