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Description
| - Six novel AChE reactivators with a (Z)-but-2-ene linker were synthesized using the known synthetic pathways. Their ability to reactivate AChE, which had been previously inhibited by nerve agent tabun or pesticide paraoxon, was tested in vitro and compared to pralidoxime, HI-6, obidoxime, and K075. The novel synthesized compounds were found to be ineffective against GA-inhibited AChE but the ability of (Z)-1,4-bis(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide to reactivate paraoxoninhibited AChE was comparable with that of oxime K075. Notably, the oxime group in position four substantially increased the ability of the novel compounds to reactivate paraoxon-inhibited AChE.
- Six novel AChE reactivators with a (Z)-but-2-ene linker were synthesized using the known synthetic pathways. Their ability to reactivate AChE, which had been previously inhibited by nerve agent tabun or pesticide paraoxon, was tested in vitro and compared to pralidoxime, HI-6, obidoxime, and K075. The novel synthesized compounds were found to be ineffective against GA-inhibited AChE but the ability of (Z)-1,4-bis(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide to reactivate paraoxoninhibited AChE was comparable with that of oxime K075. Notably, the oxime group in position four substantially increased the ability of the novel compounds to reactivate paraoxon-inhibited AChE. (en)
- Byla připravena série nových reaktivátorů acetylcholinesterasy s (Z)-but-2-enovým spojovacím řetězcem - Syntéza a jejich testování proti tabunem a paraoxonem inhibované acetylcholinesterase. (cs)
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Title
| - Novel series of bispyridinium compounds bearing a (Z)-but-2-ene Linker - Synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase
- Novel series of bispyridinium compounds bearing a (Z)-but-2-ene Linker - Synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase (en)
- Série nových reaktivátorů acetylcholinesterasy s (Z)-but-2-enovým spojovacím řetězcem - Syntéza a jejich testování proti tabunem a paraoxonem inhibované acetylcholinesterase (cs)
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skos:prefLabel
| - Novel series of bispyridinium compounds bearing a (Z)-but-2-ene Linker - Synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase
- Novel series of bispyridinium compounds bearing a (Z)-but-2-ene Linker - Synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase (en)
- Série nových reaktivátorů acetylcholinesterasy s (Z)-but-2-enovým spojovacím řetězcem - Syntéza a jejich testování proti tabunem a paraoxonem inhibované acetylcholinesterase (cs)
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skos:notation
| - RIV/60162694:G44__/07:00001766!RIV08-MO0-G44_____
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/07:00001766
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Acetylcholinesterase; Reactivation; Nerve agent; Tabun; Pesticide; Paraoxon; Reactivator; Oxime (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Bioorganic and Medicinal Chemistry Letters
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Doležal, Martin
- Dohnal, Vlastimil
- Kuča, Kamil
- Musílek, Kamil
- Jun, Daniel
- Opletalová, Veronika
- Holas, Ondřej
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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