About: Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon

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About: Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Pouze K-27 a K-48 byly schopny statisticky významně chránit potkany exponované methyl-paraoxonu. Přes nižší inhibiční účinnost (vyšší IC50) methyl-paraoxonu ve srovnání s paraoxonem (poměr 4:1), schopnost oximových reaktivátorů chránit před methyl-paraoxonem indukovanou mortalitou byla snížena ve srovnání s ochranou před paraoxonem (ethylový analog). (cs) Only K-27 and K-48 provided statistically significant protection in rats exposed to methyl-POX. Despite the lower inhibitory potency (higher IC50) of methyl-POX compared with POX (ratio 4:1), the ability of oximes reactivators to protect from methyl-POX induced mortality was reduced compared with protection with POX (ethyl analog). Only K-27 and K-48 provided statistically significant protection in rats exposed to methyl-POX. Despite the lower inhibitory potency (higher IC50) of methyl-POX compared with POX (ratio 4:1), the ability of oximes reactivators to protect from methyl-POX induced mortality was reduced compared with protection with POX (ethyl analog). (en)
Title	Pět oximů (K-27, K-48, obidoxim, HI-6 a trimedoxim) ve srovnání s pralidoximem: přežití potkanů exponovaných methyl-paraoxonu (cs) Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon (en)
skos:prefLabel	Pět oximů (K-27, K-48, obidoxim, HI-6 a trimedoxim) ve srovnání s pralidoximem: přežití potkanů exponovaných methyl-paraoxonu (cs) Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon (en)
skos:notation	RIV/60162694:G44__/07:00001751!RIV08-MO0-G44_____
http://linked.open.../vavai/riv/strany	453-457
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(OBVLAJEP20032)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Kassa, Jiří Kuča, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	422153
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/07:00001751
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	organophosphates; oxime; methyl-paraoxon; cholinesterase (en)
http://linked.open.../riv/klicoveSlovo	cholinesterase methyl-paraoxon organophosphates oxime
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C72B8C958141]
http://linked.open...i/riv/nazevZdroje	Journal of Applied Toxicology
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	C-AGENTS - Medical problem of human being, animal andplant protection against topical types of military useable chemical agents
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Kassa, Jiří Kuča, Kamil Nurulain, S. M. Petroianu, G. A. Shafiullah, M. Nagelkerke, N.
issn	0260-437X
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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