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rdf:type
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Description
| - This work introduces a new approach connecting vibrational spectroscopy with homology and energetic molecular modeling of proteins. Combination of both methods can compensate their disadvantages and result in realistic three-dimensional protein models. The approach is most powerful for membrane proteins or glycoproteins with high carbohydrate content where X-ray or NMR analysis is not always successful. Nevertheless, it can also serve as a tool of preliminary analysis of any protein with unknown structure. Power of the approach is demonstrated on human alpha(1)-acid glycoprotein. Its predicted structure published in [V. Kopecky Jr. et al., Biochem. Biophys. Res. Commun. 300 (2003), 41-46] is discussed in detail with respect to the approach and its general employment.
- This work introduces a new approach connecting vibrational spectroscopy with homology and energetic molecular modeling of proteins. Combination of both methods can compensate their disadvantages and result in realistic three-dimensional protein models. The approach is most powerful for membrane proteins or glycoproteins with high carbohydrate content where X-ray or NMR analysis is not always successful. Nevertheless, it can also serve as a tool of preliminary analysis of any protein with unknown structure. Power of the approach is demonstrated on human alpha(1)-acid glycoprotein. Its predicted structure published in [V. Kopecky Jr. et al., Biochem. Biophys. Res. Commun. 300 (2003), 41-46] is discussed in detail with respect to the approach and its general employment. (en)
- Nové metody pro rychlý odhad struktur proteinu byly vyvíjeny a vysvětleny na příkladu lidského orosomukoidu (cs)
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Title
| - Vibrational spectroscopy and computer modeling of proteins: solving structure of alpha(1)-acid glycoprotein
- Vibrational spectroscopy and computer modeling of proteins: solving structure of alpha(1)-acid glycoprotein (en)
- Vibrační spektroskopie a počítačové modelování proteinu: řešení struktury alpha-1-kyselého glykoproteinu (cs)
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skos:prefLabel
| - Vibrational spectroscopy and computer modeling of proteins: solving structure of alpha(1)-acid glycoprotein
- Vibrational spectroscopy and computer modeling of proteins: solving structure of alpha(1)-acid glycoprotein (en)
- Vibrační spektroskopie a počítačové modelování proteinu: řešení struktury alpha-1-kyselého glykoproteinu (cs)
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skos:notation
| - RIV/60076658:12640/04:00005714!RIV/2005/GA0/126405/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GP206/03/D082), P(LN00A141)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60076658:12640/04:00005714
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Raman spectroscopy;fourier transform infrared spectroscopy;molecular modeling;orosomucoid;binding site;thermal dynamics (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Spectroscopy - An International Journal
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Hofbauerová, Kateřina
- Kopecký, Vladimír
- Baumruk, Vladimír
- Ettrich, Rudiger Horst
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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