About: Cyclic nitrones linked to polycyclic aromatic hydrocarbons as a novel approach to DNA intercalators: synthesis and docking studies

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We present a synthesis of new derivatives of PAHs that are coupled together with functionalized five-membered cyclic nitrones via a C=C spacer. Synthetic protocol is based on our experience in the allenyloxime chemistry. We examined the effect on calculated DNA intercalation parameters that reflected the interaction of the functionalized nitrone moiety with DNA backbone. We present a synthesis of new derivatives of PAHs that are coupled together with functionalized five-membered cyclic nitrones via a C=C spacer. Synthetic protocol is based on our experience in the allenyloxime chemistry. We examined the effect on calculated DNA intercalation parameters that reflected the interaction of the functionalized nitrone moiety with DNA backbone. (en)
Title	Cyclic nitrones linked to polycyclic aromatic hydrocarbons as a novel approach to DNA intercalators: synthesis and docking studies Cyclic nitrones linked to polycyclic aromatic hydrocarbons as a novel approach to DNA intercalators: synthesis and docking studies (en)
skos:prefLabel	Cyclic nitrones linked to polycyclic aromatic hydrocarbons as a novel approach to DNA intercalators: synthesis and docking studies Cyclic nitrones linked to polycyclic aromatic hydrocarbons as a novel approach to DNA intercalators: synthesis and docking studies (en)
skos:notation	RIV/00216224:14310/10:00048828!RIV11-GA0-14310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA203/09/1345)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Potáček, Milan Buchlovič, Marian Kříž, Zdeněk
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	252595
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/10:00048828
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	allenes; oximes; nitrones; DNA intercalators (en)
http://linked.open.../riv/klicoveSlovo	allenes oximes nitrones DNA intercalators
http://linked.open...ontrolniKodProRIV	[36AA29D74948]
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Allenyl synthon in synthesis of heterocyclic compounds
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Buchlovič, Marian Potáček, Milan Kříž, Zdeněk
http://localhost/t...ganizacniJednotka	14310

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